There is a body of Supreme Court rulings “around” the 10th Amendment. But, it’s ambiguous and the 10th and the 9th remain weak and gutted by the “Commerce Clause”.
"The Ninth Amendment warns against drawing any inferences about the scope of the people’s rights from the partial listing of some of them. The Tenth Amendment warns against using a list of rights to infer powers in the national government that were not granted. In referring, respectively, to “rights . . . retained by the people” and “powers . . . reserved . . . to the people,” the Ninth and Tenth Amendments also evoke themes of popular sovereignty, highlighting the foundational role of the people in the constitutional republic.
The Tenth Amendment’s simple language—“The powers not delegated to the United States by the Constitution, nor prohibited by it to the States, are reserved to the States respectively, or to the people”—emphasizes that the inclusion of a bill of rights does not change the fundamental character of the national government." – The National Constitution Center
We should encourage a group of State Attorney Generals to find a good common case based on the 10th and run it through the Federal Court system. Hopefully to get it to SCOTUS. We need to revive the 9th and particularly the 10th amendments to make them “work” for us. This could be the start of of the END of “something big”.